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KMID : 0828620070110010007
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Journal of Korean Arthroscopy Society
2007 Volume.11 No. 1 p.7 ~ p.12
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Changes of Synovial Fluid Cytokine in Anterior Cruciate Ligament Injury
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Kim Sung-Hun
Lee Woo-Suk
Chung Whan-Young
Heo Youn-Moo
Kim Tae-Gyun
Cho Sung-Kwon
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Abstract
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Purpose:The purpose of our study was to determine the concentrations of cytokines in ACL deficient knee, the changes of cytokines from injury as the time progressed, and changes of cytokines after ACL reconstruction.
Materials and Method :Twenty-five patients with ACL-injured knee were enrolled. Synovial fluid lavages were collected at the time of surgery. Before surgery, twenty-five patients were aspirated synovial fluid from their injured and uninjured knees. Twelve patients were aspirated synovial fluid after 9 months postoperatively. The samples were analysed for IL-1β, TNF-α, MMP-3, IL-6 and TIMP-1 using ELISA.
Results:The IL-1βand TNF-αconcentrations were below detectable ranges in all uninjured knees and ACL ruptured knees. There were no significant difference between the mean concentrations of the uninjured and ACL injured knees for TIMP-1 and IL-6. The mean concentration of MMP-3 in ACL injured knees was significantly higher than in the uninjured knees. In the 12 cases after 9 months postoperatively, the mean concentration of MMP-3 was no significant difference between preoperative cytokine levels.
Conclusions: The concentration of MMP-3 was only higher in the ACL injured knee than uninjured knee and no significant change was examined after 9 months postoperatively.
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KEYWORD
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Anterior Cruciate Ligament, Cytokine
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